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KMID : 1134820120410010007
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 1 p.7 ~ p.13
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Hepatoprotective Effect of Curdrania tricuspidata Extracts against Oxidative Damage
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Kim Ok-Kyung
Ho Jin-Nyoung
Nam Da-Eun
Jun Woo-Jin
Hwang Kwon-Tack
Kang Jung-Eun
Chae Ok-Soon
Lee Jeong-Min
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Abstract
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We investigated the antioxidant and hepatoprotective effects of extracts from the leaves, stems, and fruit of Cudrania tricuspidata (CT) against H2O2 or ethanol-induced oxidative damage. The total polyphenol and flavonoid content was the highest in the 80% ethanol extracts from the leaves of the plant (CTL80). Also, the radical scavenging activity of DPPH and ABTS in the CTL80 was significantly higher than that of the non-treated control. To determine the hepatoprotective effects of CT in H2O2 and ethanol-induced oxidative damage, cell viability was measured using an XTT assay. Pre-treatment of CTL80 significantly increased cell viability compared with the non-treated control cells by 71.21% and 80.40%, respectively. The data suggests that CTL80 exhibits hepatoprotective antioxidant effects. Therefore, CTL80 may be considered a potential agent to control H2O2 or ethanol-induced liver damage.
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KEYWORD
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Cudrania tricuspidata, antioxidative activity, hepatoprotective effect, oxidative stress
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